All are described in human medicine but few have been studied in dogs (6,12). administration of meloxicam, carprofen, and CS-G-M did not affect canine thyroid function evaluation. Introduction Canine RIP2 kinase inhibitor 2 hypothyroidism is a RIP2 kinase inhibitor 2 frequent endocrinopathy in dogs, and the clinical signs are numerous, variable, often nonspecific, and rarely pathognomonic (1,2,3,4,5,6,7,8,9,10,11,12). Therefore, thyroid function is routinely evaluated in dogs. Several diagnostic tests are available for assessing the canine thyroid function, but no single test has 100% accuracy (1,3,4,5,7,10,12,13,14,15,16,17,18,19). Moreover, severe nonthyroidal illnesses (NTI, euthyroid sick syndrome) or various drugs can affect the results of the thyroid function testing, making interpretation of the results even more difficult and with the increased risk of over diagnosing hypothyroidism (1,3,4,5,10,12,13,14,15,16,17,19,20). Numerous drugs and NTI can affect the evaluation of thyroid function by several mechanisms (6,12,21,22,23,24). Indeed, drugs can act directly by inhibition of secretions of the thyroid gland or by altering CARMA1 metabolism, metabolic clearance, and tissue uptake of thyroid hormones (12,21,22). Both drugs and NTI can interfere with serum binding of thyroid hormones (12,21,22). The conversion of thyroxine (T4) to triiodothyronine (T3) or reverse T3 (rT3) can be altered by the inhibition of the 5′-deiodinase enzyme in peripheral tissues (12,21). Glucocorticoids, phenobarbital, and trimethoprim/ sulfamethoxazole, all 3 commonly used drugs in dogs, have been shown to alter canine thyroid function (21,25,26,27). Only a few nonsteroidal anti-inflammatory drugs (NSAIDs) have been studied in the dog in the past; phenylbutazone had no significant effect on T4 binding, flunixin increased the free T4 fraction, and salicylates seemed to decrease the T4 concentration (28,29). The influences of these NSAIDs on thyroid function have been explained by competition between thyroid hormones and drugs for the binding-proteins (28,29). Many other drugs that have not been studied yet in dogs could potentially alter the evaluation of thyroid function in RIP2 kinase inhibitor 2 that species (12,30). Osteoarthritis is a common condition affecting approximatively 20% of the canine population over 1 y of age (31). This degenerative disease is typically manifested in dogs by pain and lameness (31,32,33,34,35,36). The newest NSAIDs and the slow-acting disease modifying osteoarthritis agents (SADMOAs) are commonly used because they allow for better control of chronic pain, improvement of general mobility, slower progression of the disease, and, therefore, improvement in the quality of life (32,34,36,37,38). Among approved NSAIDs for the long-term therapy of osteoarthritis, there are meloxicam (Metacam; Boeringher-Ingelheim, Burlington, Ontario) and carprofen (Rimadyl; Pfizer, London, Ontario) (39,40). An SADMOA sold as a nutraceutical (nutritional supplement), which contains chondroitin sulfate, purified glucosamine, and manganese ascorbate (CS-G-M) (Cosequin; Nutramax Laboratories, Edgewood, Maryland, USA), can decrease progression of the degenerative joint diseases and control both inflammation and pain (37,38,41). There is a consensus that the use of a drug for a long period of time can produce side effects or can alter the RIP2 kinase inhibitor 2 functions of different body systems. A recent study on 21 dogs receiving the NSAID carprofen for 2 to 5 wk showed that this drug can significantly decrease both serum total thyroxine (TT4) concentration and endogenous thyroxine stimulating hormone (TSHc) concentration; free thyroxine (FT4) concentration, however, was not modified by carprofen in this study (42). Canine hypothyroidism affects typically medium to large breeds from 2 to 6 y old RIP2 kinase inhibitor 2 (12). This human population of canines can be even more in danger for osteoarthritis and in addition, thus, for getting an NSAID or an SADMOA to boost their standard of living and their joint wellness (31). In the eventuality that canines getting either an NSAID or an SADMOA for osteoarthritis are offered medical signs appropriate for hypothyroidism, it should be known if these medicines influence the full total outcomes of.